經(jīng)省中醫(yī)藥管理局推薦，以下課題擬參加2011年度的浙江省科技進步獎評審，特此公示 ：

課題名稱：黃芩甙對急性壞死性胰腺炎炎癥介質(zhì)及多臟器細胞凋亡的影響
主要完成單位：杭州市第一人民醫(yī)院
主要完成人員的項目分工：張喜平（課題設計、實施、管理、總結）、封光華（課題實施）、王克義（血清檢測）、徐如君（病理檢測）、嚴偉（黃芩甙/苷注射液制備）、程琪輝（資料整理）   
獲得的知識產(chǎn)權證明：“一種黃芩苷液配制方法”獲得國家發(fā)明專利，專利授權號ZL200310122673.6

 發(fā)表的10篇代表性論文目錄：
(1).Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis.Pancreas. 2009 ;38(7):732-8.  
(2).Effects of Baicalin and Octreotide on inflammatory mediators and pancreatic acinar cell apoptosis in rats with severe acute pancreatitis.Journal of research in medical sciences(JRMS).2009,14(1):19-27 
(3). Effect of baicalin and octreotide on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2009,24(11):1753-1762  
(4). Progress of study on the relationship between mediators of inflammation and apoptosis in acute pancreatitis.Dig Dis SCI. 2007 May;52(5):1199-205  
(5).Experimental study of therapeutic efficacy of Baicalin in rats with severe acute pancreatitis.World J Gastroenterol. 2007;13(5):717-24.  
(6).Pathological changes in multiple organs of rats with severe acute pancreatitis treated by baicalin and octreotide.Hepatobiliary Pancreat Dis Int. 2009;8(1):85-92. 
(7).Influence of Baicalin and Octreotide on NF-kappaB and P-Selectin Expression in Liver and Kidney of Rats with Severe Acute Pancreatitis.Inflammation. 2009;32(1):1-11. 
(8). Protective Effects of Baicalin and Octreotide on Multiple Organ Injury in Severe Acute Pancreatitis.Dig Dis Sci. 2008 Feb;53(2):581-591. 
(9).The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP.Mediators Inflamm. 2007;2007:19469.  
(10).Effects of Baicalin and Octreotide on the Serum TNF-α Level and Apoptosis in Multiple Organs of Rats with Severe Acute Pancreatitis. In?ammation, 2009,32(3):191-201   

取得的社會經(jīng)濟效益：

(1)本課題有望為ANP的治療提供一種價廉、效好的新藥；
(2)已經(jīng)建立起了900多只ANP大鼠的多臟器組織芯片庫，將為國內(nèi)外其他學者的相關研究提供方便；
(3)課題負責人提出的多臟器病理評分標準陸續(xù)發(fā)表在SCI期刊，并已有學者采用，有望得到進一步推廣和應用；
(4)截止2010年1月課題負責人作為第一作者或第二作者（兼通訊作者）在國內(nèi)外已經(jīng)發(fā)表與課題相關的論文49篇，其中在一級期刊發(fā)表19篇，二級期刊發(fā)表14篇?？偣灿?6篇論文被SCI收錄，其中9篇共被他引28次；總共有34篇中文論文被他引437次。